About fIVE DB

fIVE DB (from In Vitro Experiments DataBase) is an InSysBio UK Ltd project for in vitro experiments information collection and processing.

fIVE DB contains the quantitative data obtained in vitro and ex vivo for human cells or cell lines. The data describes major cell processes such as proliferation, cell death, differentiation, activation, secretion, and others. Data is collected from the public domain sources, processed, and stored in the fIVE DB as content.

Data processing includes the calculation of parameters suitable for cell process description with mathematical models. Parameters calculation is based on the InSysBio way of regulators impact implementation in the models (more details here) and pre-derived equations describing typical in vitro experiments (please find more information here).

Key features of fIVE DB:

Search by cell or by process type
The query may include Regulator (activator or inhibitor) or Modifier of the process rate, parameter name (in the terms proposed by InSysBio for regulators effect description), tissue type, and patient group type (healthy control or disease type)
Table representation of the search results with possibility of export to the CSV format

Content of fIVE DB:

331 process regulators molecules, press to view details;
- 12-Hydroxyeicosatetraenoic acid
- 15(R)-Hydroxyeicosatetraenoic acid
- 1-Methyl-4-phenylpyridinium
- 3-Hydroxyanthranilic acid
- 5'-Adp
- 5'-Atp
- 5-oxo-ETE
- Acetate
- Acetylcholine
- Adenosine
- Adiponectin
- Adrenalin
- Albumin
- Aldosterone
- Alpha-synuclein
- Alprostadil
- Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
- Amphiregulin
- aMSH
- Amyloid beta (1-40)
- Amyloid beta (1-42)
- Amyloid beta (25-35)
- Angiopoietin-1
- Angiopoietin-2
- Angiotensin II
- antibacterial protein LL-37
- anti-CD28
- anti-CD3
- Apelin
- Appetite-regulating hormone
- Ascorbic acid
- As-MIF
- Beryllium sulfate
- Beta-2-microglobulin
- Beta-defensin 103
- Beta-nerve growth factor
- BMP-4
- Bone morphogenetic protein 6
- Bradykinin
- Brain-derived neurotrophic factor (BDNF)
- Butyrate
- C1q-related factor
- C3 binding glycoprotein
- C5a anaphylatoxin chemotactic receptor 1
- Calcitriol
- Calcium Chloride
- Calcium pyrophosphate dihydrate
- Calprotectin
- Capsid protein
- Cardiotrophin-1
- C-C motif chemokine 18
- C-C motif chemokine 19
- C-C motif chemokine 2
- C-C motif chemokine 20
- C-C motif chemokine 21
- C-C motif chemokine 25
- C-C motif chemokine 3
- C-C motif chemokine 4
- C-C motif chemokine 5
- C-C motif chemokine 7
- CCN family member 1
- CCN family member 2
- CCN family member 4
- CD40L
- Cellular communication network factor 6
- Chorionic somatomammotropin hormone 1
- Chymase
- Coagulation factor X
- Collagen alpha-1(IV) chain
- Complement C3
- Complement C5
- Complement factor H
- Concanavalin A
- CoQ10
- Corticoliberin
- Cortisol
- C-reactive protein
- C-X-C motif chemokine 10
- C-X-C motif chemokine 11
- C-X-C motif chemokine 13
- C-X-C motif chemokine 3
- C-X-C motif chemokine 9
- CXCL16
- CXCL2
- CXCL4
- CXCL4L1
- cyclic GMP-AMP
- Cycloheximide
- Defensin beta 4A
- Dermcidin-1L (DCD-1L)
- Dopamine
- Eluted antigen of P. acnes
- Endoplasmic reticulum aminopeptidase 1
- Endoplasmic reticulum aminopeptidase 2
- Endothelin-1
- Enterotoxin type B
- Env polyprotein
- Eosinophil cationic protein
- Eotaxin
- Erythropoietin
- Estradiol
- Ethanol
- Ferric citrate
- FGF
- Fibroblast growth factor 2
- Fibroblast growth factor 7
- Fibronectin
- Flagellin
- Folic acid
- Formate
- Fractalkine
- FSTL1
- Galectin-10
- GD1a
- GD1b
- GD2
- GH (growth hormone/somatotropin)
- Glia maturation factor
- Glucagon
- Glucose
- Glutamine
- Glutathione
- GM1
- GM2
- gp120
- gp160 (HIV-1)
- GQ1b
- Granulocyte colony-stimulating factor
- Granulocyte-macrophage colony-stimulating factor
- Granzyme K
- Growth-regulated alpha protein
- GT1b
- hBD-1 (human β-defensin 1)
- hBD-4 (human β-defensin 4)
- hCG
- Hepatocyte growth factor
- High mobility group box 1 (HMGB1, amphoterin)
- Histamine
- HNP-1 (a-defensin-1)
- Hsp70
- Hydrogen Peroxide
- iE-DAP
- IFNa
- IgA
- IgE
- IGF1
- IGFBP-5
- IgG
- IgG2
- IL1
- IL12
- IL23 (p19/p40)
- IL27
- IL35
- Inhibin A
- Inhibin beta A chain
- Insulin
- Insulin-like growth factor II
- Insulin-like growth factor-binding protein 3
- Interferon alpha-2
- Interferon beta
- Interferon gamma
- Interferon lambda-1
- Interferon lambda-2
- Interferon lambda-3
- Interleukin-1 alpha
- Interleukin-1 beta
- Interleukin-1 receptor antagonist protein
- Interleukin-10
- Interleukin-11
- Interleukin-13
- Interleukin-15
- Interleukin-17A
- Interleukin-17F
- Interleukin-18
- Interleukin-18-binding protein
- Interleukin-19
- Interleukin-2
- Interleukin-21
- Interleukin-22
- Interleukin-24
- Interleukin-25
- Interleukin-26
- Interleukin-3
- Interleukin-31
- Interleukin-32
- Interleukin-33
- Interleukin-34
- Interleukin-36 alpha
- Interleukin-36 beta
- Interleukin-36 gamma
- Interleukin-37
- Interleukin-4
- Interleukin-5
- Interleukin-6
- Interleukin-7
- Interleukin-8
- Interleukin-9
- Interstitial collagenase
- Ionomycin
- Islet amyloid polypeptide
- Isoform 1 of Interleukin-32
- Isoform 2 of Interleukin-32
- Isoform 2 of Interleukin-6 receptor subunit alpha
- Isoform 4 of Interleukin-32
- Kit ligand
- Laminin subunit alpha-1
- Lauric Acid
- Leptin
- Leukotriene B4
- leukotriene C4
- Leukotriene D4
- Leukotriene E4
- LIF
- Lipopolysaccharide-binding protein
- lipoxin A4
- LPS
- Lymphotoxin-a1b2
- Lymphotoxin-alpha
- Lysophosphatidylcholine
- Macrophage colony-stimulating factor 1
- Macrophage migration inhibitory factor
- Manganous cation
- Mannoprotein antigen from C. albicans
- Mannose-binding protein C
- Melanoma-associated antigen 1
- Mercuric Chloride
- Monocyte differentiation antigen CD14
- Monosodium urate crystals
- Morphine
- MSPa (macrophage stimulating protein a)
- Muramyl Dipeptide
- Myelin basic protein
- Myelin-oligodendrocyte glycoprotein
- Myristic Acid
- Natural cytotoxicity triggering receptor 3 ligand 1
- Nesfatin 1
- Neurotensin
- Neutrophil elastase
- N-Formyl-Met-Leu-Phe
- Nicotinamide phosphoribosyltransferase
- Nicotinamide riboside
- Oleate
- Oleic Acid
- Oncostatin-M
- Osteopontin
- P0
- P2b
- Palmitic Acid
- Parkinson disease protein 7
- PD1L1
- PDGF
- PDGF-AB
- Peptidase 1
- Periostin
- PGD2
- PGE2
- PHA
- Pigment epithelium-derived factor
- Platelet-Activating Factor (PAF)
- Platelet-derived growth factor subunit A
- Platelet-derived growth factor subunit B
- PMA
- Poly I:C
- Potassium
- Prasterone
- Pro-epidermal growth factor
- Progesterone
- Progesterone-induced-blocking factor 1
- Proheparin-binding EGF-like growth factor
- Pro-interleukin-16
- Prolactin
- Pro-neuropeptide Y
- Propionate
- Protein S100-A7
- Protein S100-A8
- Protein S100-A9
- Protein Tat
- Protransforming growth factor alpha
- PSG
- Pulmonary surfactant-associated protein A1
- Pyridoxal hydrochloride
- Quinolinic acid
- RANKL
- Resistin
- Ribonuclease 7
- SAP
- sCD13
- sCD40L
- Serotonin
- Serum amyloid A-1 protein
- sIgA
- Silicon Dioxide
- Sm29
- Sodium Chloride
- Sodium hydrosulfide (NaHS)
- Spermidine
- Sphingosine 1-Phosphate
- Spike glycoprotein
- Spike protein S1
- Stromal cell-derived factor 1
- Substance P
- Superoxide dismutase [Cu-Zn]
- Tax-1
- Testosterone
- Tetanus toxin
- TGFb3
- Thrombin
- Thrombopoietin
- Thymic stromal lymphopoietin
- Tissue-type plasminogen activator
- Toxic shock syndrome toxin-1
- Transforming growth factor beta-1 proprotein
- Transforming growth factor beta-2 proprotein
- Tretinoin
- Tumor necrosis factor
- Tumor necrosis factor ligand superfamily member 10
- Tumor necrosis factor ligand superfamily member 12
- Tumor necrosis factor ligand superfamily member 13
- Tumor necrosis factor ligand superfamily member 13B
- Tumor necrosis factor ligand superfamily member 14
- Tumor necrosis factor receptor superfamily member 1A
- Uridine 5'-triphosphate
- Uridine Diphosphate
- Urotensin-2
- Vascular endothelial growth factor A, long form
- VIP peptides
- Vitamin A
- Vitamin K3
- Vitamin K5
- ZnSO4
269 secretory products molecules, press to view details;
- 15-Deoxy-delta12,14-prostaglandin
- 6-Keto-prostaglandin F1alpha
- 72 kDa type IV collagenase
- A disintegrin and metalloproteinase with thrombospondin motifs 4
- A disintegrin and metalloproteinase with thrombospondin motifs 5
- Aggrecan core protein
- Amphiregulin
- Angiogenin
- Angiopoietin-1
- Angiopoietin-1 receptor
- Angiotensin (1-7)
- Angiotensin II
- ANGPTL1
- antibacterial protein LL-37
- Antileukoproteinase
- Basigin
- Beta-2-microglobulin
- Beta-defensin 103
- Beta-nerve growth factor
- Bone morphogenetic protein 2
- BPI fold-containing family A member 1
- Brain-derived neurotrophic factor (BDNF)
- Calprotectin
- Carbonic anhydrase-2
- Caspase-1
- Caspase-1 p20
- Cathelicidin antimicrobial peptide
- C-C motif chemokine 1
- C-C motif chemokine 13
- C-C motif chemokine 17
- C-C motif chemokine 18
- C-C motif chemokine 19
- C-C motif chemokine 2
- C-C motif chemokine 20
- C-C motif chemokine 21
- C-C motif chemokine 22
- C-C motif chemokine 23
- C-C motif chemokine 24
- C-C motif chemokine 26
- C-C motif chemokine 27
- C-C motif chemokine 3
- C-C motif chemokine 4
- C-C motif chemokine 5
- C-C motif chemokine 7
- C-C motif chemokine 8
- CCL28
- CCN family member 4
- Cell adhesion molecule CEACAM1
- Cell adhesion molecule CEACAM6
- Cell adhesion molecule CEACAM8
- Ceruloplasmin
- Collagen alpha-1(II) chain
- Collagen alpha-1(IV) chain
- Collagen type 1
- Collagen type 3
- Complement Bb
- Complement C3
- Complement C5
- Complement factor B
- Complement factor H
- C-reactive protein
- C-X-C motif chemokine 10
- C-X-C motif chemokine 11
- C-X-C motif chemokine 13
- C-X-C motif chemokine 3
- C-X-C motif chemokine 5
- C-X-C motif chemokine 6
- C-X-C motif chemokine 9
- CXCL16
- CXCL2
- CXCL4
- Cysteinyl leukotrienes (Cys-LTs)
- Cytochrome c oxidase subunit 2
- Decorin
- Defensin beta 4A
- DKK1
- Elafin
- Elastin
- Endostatin
- Endothelin-1
- Eosinophil cationic protein
- Eotaxin
- E-selectin
- Fas
- FasL
- FGF
- FGF5
- Fibroblast growth factor 1
- Fibroblast growth factor 2
- Fibronectin
- Fms-related tyrosine kinase 3 ligand
- Fractalkine
- Granulocyte colony-stimulating factor
- Granulocyte-macrophage colony-stimulating factor
- Growth-regulated alpha protein
- hBD-1 (human β-defensin 1)
- Heparan sulfate
- Hepatocyte growth factor
- HIF1a
- High mobility group box 1 (HMGB1, amphoterin)
- Histamine
- HNPs (defensins)
- Hsp70
- Hyaluronic acid (HA)
- Hydrogen Peroxide
- IFNa
- IgA
- IgE
- IGF1
- IgG
- IgM
- IL1
- IL12
- IL17A/F
- IL-1F10
- IL23 (p19/p40)
- IL27
- IL-27
- IL2R
- Indoleamine 2,3-dioxygenase 1
- Inhibin
- Inhibin beta A chain
- Inhibin beta B chain
- Insulin-like growth factor II
- Intercellular adhesion molecule 1
- Interferon alpha-2
- Interferon beta
- Interferon gamma
- Interferon lambda-1
- Interferon lambda-2
- Interferon lambda-3
- Interleukin-1 alpha
- Interleukin-1 beta
- Interleukin-1 receptor antagonist protein
- Interleukin-1 receptor-like 1
- Interleukin-10
- Interleukin-11
- Interleukin-12 subunit beta
- Interleukin-13
- Interleukin-15
- Interleukin-17A
- Interleukin-17F
- Interleukin-18
- Interleukin-18-binding protein
- Interleukin-19
- Interleukin-2
- Interleukin-2 receptor subunit alpha
- Interleukin-20
- Interleukin-21
- Interleukin-22
- Interleukin-23 subunit alpha
- Interleukin-24
- Interleukin-25
- Interleukin-26
- Interleukin-3
- Interleukin-31
- Interleukin-32
- Interleukin-33
- Interleukin-36 gamma
- Interleukin-37
- Interleukin-4
- Interleukin-5
- Interleukin-6
- Interleukin-7
- Interleukin-8
- Interleukin-9
- Interstitial collagenase
- Isoform 2 of Interleukin-6 receptor subunit alpha
- Isoform Short of Interleukin-1 receptor type 2
- Kit ligand
- Kynurenic acid
- Kynurenine
- Lactate
- Lactotransferrin
- Laminin subunit alpha-1
- Leukotriene B4
- leukotriene C4
- Leukotriene E4
- LIF
- Lymphotoxin-alpha
- Macrophage colony-stimulating factor 1
- Macrophage metalloelastase
- Macrophage migration inhibitory factor
- Matrix metalloproteinase 7
- Matrix metalloproteinase-9
- MCAF
- Metalloproteinase inhibitor 1
- Metalloproteinase inhibitor 2
- Metalloproteinase inhibitor 3
- Metalloproteinase inhibitor 4
- MMP-13
- MMP3
- Monocyte differentiation antigen CD14
- Mucin-5AC
- Myeloblastin
- Myeloperoxidase
- Neopterin
- Neurotrophin-4
- Neutrophil collagenase
- Neutrophil elastase
- Neutrophil gelatinase-associated lipocalin
- Nitric oxide
- Nitrite
- NLRP3
- Non-secretory ribonuclease
- Oncostatin-M
- Osteocalcin
- Osteopontin
- Osteoprotegerin
- PDGF
- PDGF-AB
- PDGF-C
- Periostin
- PGD2
- PGE2
- PGF2alpha
- Pigment epithelium-derived factor
- Placenta growth factor
- Plasmin-alpha2-plasmin inhibitor complex (PIC)
- Plasminogen activator inhibitor 1
- Platelet-Activating Factor (PAF)
- Platelet-derived growth factor subunit A
- Platelet-derived growth factor subunit B
- Pro-adrenomedullin
- Procollagen-1
- Pro-epidermal growth factor
- Progranulin
- Pro-interleukin-16
- pro-NGF
- Protein S100-A12
- Protein S100-A7
- Protein S100-A8
- Protein Wnt-5a
- Protransforming growth factor alpha
- RANKL
- Resistin
- sC5b-9
- sCD30
- sCD40L
- Semaphorin-3A
- Serum amyloid A-1 protein
- Sgp130 (Soluble Glycoprotein 130)
- sIL-1Ra
- sP-selectin
- Stromal cell-derived factor 1
- Stromelysin-2
- Superoxide
- Thrombopoietin
- Thrombospondin-1
- Thrombospondin-2
- thromboxane B2
- Thymic stromal lymphopoietin
- Thyroglobulin
- Thyroxine
- Transforming growth factor beta-1 proprotein
- Transforming growth factor beta-2 proprotein
- Tryptase alpha/beta-1
- Tumor necrosis factor
- Tumor necrosis factor ligand superfamily member 10
- Tumor necrosis factor ligand superfamily member 13B
- Tumor necrosis factor receptor superfamily member 1A
- Tumor necrosis factor receptor superfamily member 1B
- Tumor necrosis factor receptor superfamily member 5
- Vascular cell adhesion protein 1
- Vascular endothelial growth factor A, long form
- Vascular endothelial growth factor C
- Vascular endothelial growth factor D
- Vascular endothelial growth factor receptor 1
- VIP peptides
202 cell types, press to view details;
- activated alveolar macrophages
- activated aNAV B cells
- Activated B cells
- activated BMEC
- activated BMSC
- activated CD4+ T-cells
- Activated CD8+ T cells
- activated cytotoxic Treg
- activated dendritic cells
- Activated dental pulp cells
- activated endometrial stromal cells (ESC)
- activated endothelial cells
- Activated Eosinophils
- activated epithelial cells
- Activated Erythroid progenitor cells
- activated fibroblast-like synoviocytes
- activated fibroblasts
- activated gamma-delta T-cells
- activated HUVEC
- Activated iDCs
- Activated iNKT cells
- activated Innate lymphoid cells 2 (CRTH2+)
- activated keratinocytes
- Activated lymphocytes
- activated macrophages
- Activated memory B cells
- Activated memory Th1
- Activated memory Th17
- Activated monocyte-derived dendritic cells
- activated monocyte-derived macrophages
- Activated monocytes
- activated mononuclear cells
- Activated Myeloid DC cells
- activated NK-cells
- activated PBMC
- activated pDC
- activated PMN
- Activated Progenitor cells CD34+
- activated sinus lavage cells
- Activated T-cells
- activated T-cells (CD4+CD25-)
- Activated Th1
- Activated Th17
- Activated Th2
- activated Th-cells
- Activated White Blood Cells (WBC)
- Adipocytes
- Adrenocortical cells
- AG-EB+ erythroid nuclear cells
- Airway smooth muscle cell
- alpha-beta T-cells
- Amniotic epithelial cells (AECs)
- aNAV B cells
- Annulus Fibrosus cells
- Arterial endothelial cells
- Astrocytes
- B cells
- BAL cells
- Basophil progenitor cells
- Basophils
- Biliary epithelial cells
- BM erythroid cells
- BMSC
- CBMC
- CD16- monocytes
- CD16+ monocytes
- CD34+ cells
- CD56bright NK cells
- Chondrocytes
- Ciliated cells
- Conjunctival epithelial cells
- Corneal epithelial cells
- Cytokine-induced killer cells
- Cytotrophoblast cells
- Decidual stromal cell
- Dendritic Cells (DC)
- Dental Pulp Cells
- Dermal fibroblasts (DFs)
- Endometrial stromal cells (ESCs)
- Endothelial Cells
- Eosinophil
- Epidermal cells
- Epithelial cells
- Erythroblasts
- Erythroid progenitor cells
- Fibroblast-like synoviocytes
- Fibroblasts
- gamma-delta T-cells
- Gl A+ erythroid nuclear cells
- Glial cells
- Granulocytes
- Granulocytic Myeloid-Derived Suppressor Cells (G-MDSC)
- granulosa luteal cells
- Hepatic stellate cells (HSC)
- Hepatocytes
- Immature DCs (iDCs)
- Immature megakaryocytes
- iNKT
- Innate lymphoid cells 2 (CRTH2+)
- Intestinal cells
- Intraepithelial lymphocytes
- islets
- iTreg
- Keratinocytes
- Keratocytes
- Kupffer cells
- Langerhans Cells (LC)
- large granular lymphocytes (LGL)
- Leukemic blasts
- Lymphoblasts
- Lymphocytes
- Macrophages
- Malignant plasma B cells
- Mast cells
- Mature Dendritic Cells (DC)
- Mature megakaryocytes
- Megakaryoblast
- Megakaryocytes
- Melanocytes
- Memory B cells
- memory CD4 T cells
- memory CD8 T cells
- Memory mononuclear cell
- Memory T-cells
- Merkel cells
- Mesenchymal progenitor cell
- Microglial cells
- Microvascular endothelial cells
- Monocyte-derived dendritic cells
- Monocyte-derived macrophages
- Monocytes
- Monocytes/macrophages
- Mononuclear cells
- MPC
- Myeloid angiogenic cells
- Myeloid DC2
- Myeloid Dendritic Cells (mDC)
- Myoblasts
- Myofibroblasts
- Naive B cells
- Naive CD4 T cells
- Naive CD8+ T cells
- Naive mononuclear cell
- Naive T-cells
- Natural killer T-cells
- Neural crest stem-like cells (NCSCs)
- Neuroblasts
- Neuron-like cells
- Neutrophil-like cell
- Neutrophils
- NK/NK-like cells
- NK-cells
- NK-cells (CD56+)
- NKT [Natural Killer-like T-cells]
- Non-adherent mononuclear cell (NAMNC)
- Nucleus pulposus cells
- Odontoblasts
- orbital fibroblasts
- Osteoblasts (OB)
- Osteogenic-differentiated MPC (dOB)
- PBMC
- Periapical lesion cells
- Periodontal ligament cells
- Peripheral blood monocytes
- Pigment epithelium
- Plasma B cells
- Plasmacytoid Dendritic Cells (pDC)
- Platelets
- Podocytes
- Pre-adipocytes
- precursor B cells
- Promyeloblasts
- Retinal Muller glial cells
- Retroorbital fibroblasts
- sebocytes
- Sinus lavage cells
- Smooth muscle cells
- Spermatozoa
- Sputum cells
- Stem cells
- Stromal cells
- Stromovascular cells
- Synoviocytes
- Tc1-cell
- Tc-cells
- T-cells
- Th1
- Th17-cells
- Th1-cells
- Th22-cells
- Th2-cells
- Th9-cells
- Th-cells
- Thyrocytes
- TIMC
- Tonsillar B cells
- Transitional B cells
- Treg-cells
- Trophoblasts
- Tumor cells
- White Blood Cells (WBC)
- Whole blood cells
427 parameters for Migration.
869 parameters for Cell Death.
322 parameters for Proliferation.
44202 parameters for Secretion.
109 parameters for Differentiation.
3 parameters for Cytokine degradation.
data extracted from 2360 papers/other public sources.

Access to fIVE DB

Versions of the database:

• Commercial version entitled as “fIVE DB”

• Public version entitled as “fIVE DB Open”

fIVE DB

• fIVE DB is a version of the database which is accessible via purchasing the commercial license

• To arrange the purchase, please contact us by email: support@insysbio.com

• Both content and functionality of fIVE DB is described above and updated on the monthly basis

fIVE DB Open version

• fIVE DB Open is a version of the database which is accessible for public use

• To access fIVE DB Open, please visit 5db-open.insysbio.com

• fIVE DB Open has the same functionality as fIVE DB

• Content of fIVE DB Open is described at 5db-open.insysbio.com

• Both content and functionality of fIVE DB Open will be updated once per year

e-mail for correspondence: support@insysbio.com

About fIVE DB

331 process regulators molecules, press to view details;

269 secretory products molecules, press to view details;

202 cell types, press to view details;